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Article

Toxic death-case after capecitabine + oxaliplatin (XELOX) administration: probable implication of dihydropyrimidine deshydrogenase deficiency.

Cancer chemotherapy and pharmacology - 1 Aug 2006

Ciccolini Joseph, Mercier Cedric, Dahan Laetitia, Evrard Alexandre, Boyer Jean-Christophe, Richard Karine, Dales Jean-Philippe, Durand Alain, Milano Gerard, Seitz Jean-François, Lacarelle Bruno

Abstract excerpt

This report here is the case of a 52-year-old male patient who suffered from extremely severe haematological toxicities (G4 neutropenia, G4 thrombocytopenia) while undergoing Xelox (Xeloda + Oxaliplatin) treatment for his multifocal hepatocarcinoma. Despite appropriate supportive treatment, his condition quickly deteriorated and led to death. It was hypothesized that dihydropyrimidine deshydrogenase (DPD) gene...

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Share to Capecitabine
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Deoxycytidine

Share to Dihydrouracil Dehydrogenase (NADP)

Share to Fluorouracil

Share to Organoplatinum Compounds

Share to Oxaliplatin

Share to Tomography, X-Ray Computed

Source

Identifiers

PMID: 16292536
DOI: 10.1007/s00280-005-0139-8

Genes

DPYD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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