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Article

Regulatory Mechanisms Controlling Human Hepatocyte Nuclear Factor 4α Gene Expression

1 Nov 2001

Abstract excerpt

Hepatocyte nuclear factor 4alpha (HNF-4alpha) (nuclear receptor 2A1) is an essential regulator of hepatocyte differentiation and function. Genetic and molecular evidence suggests that the tissue-restricted expression of HNF-4alpha is regulated mainly at the transcriptional level. As a step toward understanding the molecular mechanism involved in the transcriptional regulation of the human HNF-4alpha gene, we...

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Identifiers

PMID: 11585914
DOI: 10.1128/mcb.21.21.7320-7330.2001

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