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Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells.

Molecular and cellular biology - 1 Oct 2015

Vuong Linh M, Chellappa Karthikeyani, Dhahbi Joseph M, Deans Jonathan R, Fang Bin, Bolotin Eugene, Titova Nina V, Hoverter Nate P, Spindler Stephen R, Waterman Marian L, Sladek Frances M

Abstract excerpt

The nuclear receptor hepatocyte nuclear factor 4α (HNF4α) is tumor suppressive in the liver but amplified in colon cancer, suggesting that it also might be oncogenic. To investigate whether this discrepancy is due to different HNF4α isoforms derived from its two promoters (P1 and P2), we generated Tet-On-inducible human colon cancer (HCT116) cell lines that express either the P1-driven (HNF4α2) or P2-driven...

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Identifiers

PMID: 26240283
DOI: 10.1128/MCB.00030-15
PMCID: PMC4573706

Genes

TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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