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Article

A missense mutation of mouse OCTN2, a sodium-dependent carnitine cotransporter, in the juvenile visceral steatosis mouse.

Biochemical and biophysical research communications - 27 Nov 1998

Lu K m, Nishimori H, Nakamura Y, Shima K, Kuwajima M

Abstract excerpt

Carnitine is an essential cofactor for the mitochondrial beta-oxidation of long-chain fatty acids. The juvenile visceral steatosis (JVS) mouse, an animal model of systemic carnitine deficiency, is inherited in an autosomal recessive manner. Recently, a human OCTN2 gene encoding a sodium-dependent carnitine cotransporter was isolated and mapped to human chromosome 5q31. Since the mouse jvs locus was assigned to...

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PMID: 9837751
DOI: 10.1006/bbrc.1998.9708

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A missense mutation of mouse OCTN2, a sodium-dependent carnitine cotransporter, in the juvenile visceral steatosis mouse.PMID 9837751Read ↗

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