Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP.

doi:10.20892/j.issn.2095-3941.2021.0193

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Article

Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP.

Cancer biology & medicine - 23 Nov 2021

Qin Yan, Chen Haizhu, Liu Peng, Zhang Changgong, Yang Jianliang, Gui Lin, He Xiaohui, Zhou Liqiang, Zhou Shengyu, Jiang Shiyu, Jiang Hongxin, Shi Yuankai

Abstract excerpt

OBJECTIVE: Limited data about the prognostic significance of BCL2 mutations and BCL2 copy number variations in diffuse large B-cell lymphoma (DLBCL) are available. This study aimed to comprehensively describe BCL2 genetic alterations in DLBCL patients, and examine correlation of BCL2, TP53 and other genetic alterations with outcomes in patients treated with R-CHOP. METHODS: Probe capture-based high-resolution...

Topics

Adenosine Monophosphate
Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
DNA Copy Number Variations
Doxorubicin
Humans
Lymphoma, Large B-Cell, Diffuse
Mutation
Prednisone
Prognosis
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-myc

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rituximab

Tumor Suppressor Protein p53

Vincristine

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Identifiers

PMID: 34806851
DOI: 10.20892/j.issn.2095-3941.2021.0193
PMCID: PMC9257313

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