Article
Reconstruction of N-acetyltransferase 2 haplotypes using PHASE.
Archives of toxicology - 1 Apr 2008
Golka Klaus, Blaszkewicz Meinolf, Samimi Mirabutaleb, Bolt Hermann M, Selinski Silvia
Abstract excerpt
The genotyping of N-acetyltransferase 2 (NAT2) by PCR/RFLP methods yields in a considerable percentage ambiguous results. To resolve this methodical problem a statistical approach was applied. PHASE v2.1.1, a statistical program for haplotype reconstruction was used to estimate haplotype pairs from NAT2 genotyping data, obtained by the analysis of seven single nucleotide polymorphisms relevant for Caucasians. In...
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