Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Refinement of the prediction of N-acetyltransferase 2 (NAT2) phenotypes with respect to enzyme activity and urinary bladder cancer risk.

Archives of toxicology - 1 Dec 2013

Selinski Silvia, Blaszkewicz Meinolf, Ickstadt Katja, Hengstler Jan G, Golka Klaus

Abstract excerpt

Polymorphisms of N-acetyltransferase 2 (NAT2) are well known to modify urinary bladder cancer risk as well as efficacy and toxicity of pharmaceuticals via reduction in the enzyme's acetylation capacity. Nevertheless, the discussion about optimal NAT2 phenotype prediction, particularly differentiation between different degrees of slow acetylation, is still controversial. Therefore, we investigated the impact of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arylamine N-Acetyltransferase
Share to Caffeine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Isoniazid

Share to Phosphodiesterase Inhibitors

Share to Real-Time Polymerase Chain Reaction

Share to Risk Assessment

Share to Smoking

Share to Urinary Bladder Neoplasms

Source

Identifiers

PMID: 24221535
DOI: 10.1007/s00204-013-1157-7

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Refinement of the prediction of N-acetyltransferase 2 (NAT2) phenotypes with respect to enzyme activity and urinary bladder cancer risk.PMID 24221535Read ↗

Differential association for N-acetyltransferase 2 genotype and phenotype with bladder cancer risk in Chinese population.Semantic proximity Read ↗

NAT2 slow acetylation and bladder cancer risk: a meta-analysis of 22 case-control studies conducted in the general population.Semantic proximity Read ↗

Association Between N-acetyltransferase 2 Polymorphism and Bladder Cancer Risk: Results From Studies of the Past Decade and a Meta-Analysis.Semantic proximity Read ↗

A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background.Semantic proximity Read ↗

N-acetyltransferase 2 phenotype, occupation, and bladder cancer risk: results from the EPIC cohort.Semantic proximity Read ↗

Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity.Semantic proximity Read ↗

Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype.Semantic proximity Read ↗

N-Acetyltransferase-2 (NAT2) gene polymorphisms and enzyme activity in Serbs: unprecedented high prevalence of rapid acetylators in a White population.Semantic proximity Read ↗

The differential effect of NAT2 variant alleles permits refinement in phenotype inference and identifies a very slow acetylation genotype.Semantic proximity Read ↗

Concordance between the deduced acetylation status generated by high-speed: real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay.Semantic proximity Read ↗

Improvements in algorithms for phenotype inference: the NAT2 example.Semantic proximity Read ↗

Association between N-Acetyltransferase 2 Polymorphism and Bladder Cancer Risk: a Meta-Analysis in a Single Ethnic Group.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.