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Article

B cell antigen receptor-induced Rac1 activation and Rac1-dependent spreading are impaired in transitional immature B cells due to levels of membrane cholesterol.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2007

Brezski Randall J, Monroe John G

Abstract excerpt

The BCR-triggered responses of mature and transitional immature B cells differ at both the biochemical and functional level. In this study, we show that in mature B cells, BCR signaling triggers Vav phosphorylation and Rac1 activation. Furthermore, we demonstrate that although downstream actin-de...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to JNK Mitogen-Activated Protein Kinases

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Source

Identifiers

PMID: 17878342
DOI: 10.4049/jimmunol.179.7.4464

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17878342-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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