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Article

A new functional assay reveals that membrane binding is critical for overactivation of the phosphoinositide 3-kinase H1047R mutant.

The Journal of biological chemistry - 1 Mar 2026

Papafotika Alexandra, Pavlaki Maria, Lazani Vasiliki, Karamani Vasiliki Elpida, Aggelidis Dimitris, Kapella Anna, Kotzampasi Danai Maria, Agianian Bogos, Efstratiadis Argiris, Cournia Zoe, Christoforidis Savvas

Abstract excerpt

PIK3CA encodes the catalytic subunit of class I PI3Kα (p110α), a key enzyme in receptor-mediated signaling that phosphorylates phosphatidylinositol-4,5-bisphosphate to the 3,4,5-triphosphate lipid. This gene is frequently mutated in cancers, with H1047R and E545K being the most prevalent mutations. However, the mechanisms of mutants' overactivation remain incompletely understood. Here, we report the development...

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Identifiers

PMID: 41581885
DOI: 10.1016/j.jbc.2026.111207
PMCID: PMC12934285

Genes

PIK3CA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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