Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis.

doi:10.1016/j.clinbiochem.2008.08.081

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Article

Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis.

Clinical biochemistry - 1 Nov 2008

Djurić Tamara, Zivković Maja, Radak Djordje, Jekić Djole, Radak Sandra, Stojković Ljiljana, Raicević Ranko, Stanković Aleksandra, Alavantić Dragan

Abstract excerpt

OBJECTIVES: Stromelysin-1 (MMP-3) as a key member of metalloproteinase family could have an important role in atherogenesis. The 5A/6A polymorphism in the promoter of MMP-3 gene affects the level of MMP-3 gene expression. We assessed whether the MMP-3 promoter low- and high-activity genotypes are related to susceptibility for carotid atherosclerosis (CA) in Serbian population. DESIGN AND METHODS: The study group...

Topics

Adult
Carotid Artery Diseases
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Matrix Metalloproteinase 3
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 18801353
DOI: 10.1016/j.clinbiochem.2008.08.081

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