Article
Transcription factors and the cardiac gene programme.
The international journal of biochemistry & cell biology - 1 Apr 1996
Doevendans P A, van Bilsen M
Abstract excerpt
During the past decade, major advances have been made in uncovering the mechanisms that switch genes on and off. Gene methylation and histones play an important role in gene (in)activation. Following gene activation, the initiation of transcription by RNA polymerase requires the assembly of multiple protein complexes on the promoter region of a gene. How a cell type-specific gene expression pattern can be induced...
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