Article
Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes.
Nature genetics - 1 Oct 2007
Göring Harald H H, Curran Joanne E, Johnson Matthew P, Dyer Thomas D, Charlesworth Jac, Cole Shelley A, Jowett Jeremy B M, Abraham Lawrence J, Rainwater David L, Comuzzie Anthony G, Mahaney Michael C, Almasy Laura, MacCluer Jean W, Kissebah Ahmed H, Collier Gregory R, Moses Eric K, Blangero John
Abstract excerpt
Quantitative differences in gene expression are thought to contribute to phenotypic differences between individuals. We generated genome-wide transcriptional profiles of lymphocyte samples from 1,240 participants in the San Antonio Family Heart Study. The expression levels of 85% of the 19,648 detected autosomal transcripts were significantly heritable. Linkage analysis uncovered >1,000 cis-regulated transcripts...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.