Article
Genetic analysis of genome-wide variation in human gene expression.
Nature - 12 Aug 2004
Morley Michael, Molony Cliona M, Weber Teresa M, Devlin James L, Ewens Kathryn G, Spielman Richard S, Cheung Vivian G
Abstract excerpt
Natural variation in gene expression is extensive in humans and other organisms, and variation in the baseline expression level of many genes has a heritable component. To localize the genetic determinants of these quantitative traits (expression phenotypes) in humans, we used microarrays to measure gene expression levels and performed genome-wide linkage analysis for expression levels of 3,554 genes in 14 large...
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