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Article

Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A.

Experimental cell research - 1 Jan 2008

Huang Shurong, Risques Rosa Ana, Martin George M, Rabinovitch Peter S, Oshima Junko

Abstract excerpt

LMNA mutations are responsible for a variety of genetic disorders, including muscular dystrophy, lipodystrophy, and certain progeroid syndromes, notably Hutchinson-Gilford Progeria. Although a number of clinical features of these disorders are suggestive of accelerated aging, it is not known whether cells derived from these patients exhibit cellular phenotypes associated with accelerated aging. We examined a...

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Source

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Identifiers

PMID: 17870066
DOI: 10.1016/j.yexcr.2007.08.004
PMCID: PMC2228272

Genes

LMNA
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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