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Article

Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization.

Neuroscience - 12 Oct 2007

Novakova-Tousova K, Vyklicky L, Susankova K, Benedikt J, Samad A, Teisinger J, Vlachova V

Abstract excerpt

Agonist-induced desensitization of the transient receptor potential vanilloid receptor-1 (TRPV1) is one of the key strategies that offer a way to alleviate neuropathic and inflammatory pain. This process is initiated by TRPV1 receptor activation and the subsequent entry of extracellular Ca(2+) through the channel into sensory neurones. One of the prominent mechanisms responsible for TRPV1 desensitization is...

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Source

Identifiers

PMID: 17869438
DOI: 10.1016/j.neuroscience.2007.07.039

Genes

TRPV1
PIP

Variants

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Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization.PMID 17869438Read ↗

Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding.Semantic proximity Read ↗

Carboxyl-terminal domain of transient receptor potential vanilloid 1 contains distinct segments differentially involved in capsaicin- and heat-induced desensitization.Semantic proximity Read ↗

Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway.Semantic proximity Read ↗

A tyrosine residue in TM6 of the Vanilloid Receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents.Semantic proximity Read ↗

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Functionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel--an overview of the current mutational data.Semantic proximity Read ↗

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