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Article

Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding.

The Journal of biological chemistry - 20 Feb 2004

Jung Jooyoung, Shin Jae Soo, Lee Soon-Youl, Hwang Sun Wook, Koo Jaeyeon, Cho Hawon, Oh Uhtaek

Abstract excerpt

Vanilloid receptor 1 (VR1), a capsaicin receptor, is known to play a major role in mediating inflammatory thermal nociception. Although the physiological role and biophysical properties of VR1 are known, the mechanism of its activation by ligands is poorly understood. Here we show that VR1 must be phosphorylated by Ca2+-calmodulin dependent kinase II (CaMKII) before its activation by capsaicin. In contrast, the...

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Identifiers

PMID: 14630912
DOI: 10.1074/jbc.M311448200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding.PMID 14630912Read ↗

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