Article
Interactions between the adducin 2 gene and antihypertensive drug therapies in determining blood pressure in people with hypertension.
BMC medical genetics - 13 Sept 2007
Kardia Sharon L R, Sun Yan V, Hamon Sara C, Barkley Ruth Ann, Boerwinkle Eric, Turner Stephen T
Abstract excerpt
BACKGROUND: As part of the NHLBI Family Blood Pressure Program, the Genetic Epidemiology Network of Arteriopathy (GENOA) recruited 575 sibships (n = 1583 individuals) from Rochester, MN who had at least two hypertensive siblings diagnosed before age 60. Linkage analysis identified a region on chromosome 2 that was investigated using 70 single nucleotide polymorphisms (SNPs) typed in 7 positional candidate genes,...
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