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Article

A variant of the Cockayne syndrome B gene ERCC6 confers risk of lung cancer.

Human mutation - 1 Jan 2008

Lin Zhongning, Zhang Xuemei, Tuo Jingsheng, Guo Yongli, Green Bridgett, Chan Chi-Chao, Tan Wen, Huang Ying, Ling Wenhua, Kadlubar Fred F, Lin Dongxin, Ning Baitang

Abstract excerpt

Cockayne syndrome B protein (ERCC6) plays an essential role in DNA repair. However, the Cockayne syndrome caused by the ERCC6 defect has not been linked to cancer predisposition; likely due to the fact that cells with severe disruption of the ERCC6 function are sensitive to lesion-induced apoptos...

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Source

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Identifiers

PMID: 17854076
DOI: 10.1002/humu.20610
PMCID: PMC2441604

Genes

ERCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17854076-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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