Article

Studies on the Functionality of the TC-NER ERCC6- M1097V Protein Variant Frequently Found in Louisiana PCa Patients Upon UV Damage

2025-06-12

Abstract excerpt

ERCC6, also known as CSB (Cockayne Syndrome B), is a key protein involved in transcription-coupled nucleotide excision repair (TC-NER), a DNA repair process that removes lesions blocking RNA polymerase. ERCC6’s multifaceted roles include chromatin remodeling, transcription regulation, oxidative stress response, and coordination with other DNA repair proteins. Mutations in ERCC6 lead to Cockayne Syndrome and...

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Literature Corpus work: bfdc0bf2-11b8-5579-8dad-0f74db82faf7
DOI: 10.20944/preprints202506.0979.v1

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