Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GATA4 and GATA6 control mouse pancreas organogenesis.

The Journal of clinical investigation - 1 Oct 2012

Carrasco Manuel, Delgado Irene, Soria Bernat, Martín Francisco, Rojas Anabel

Abstract excerpt

Recently, heterozygous mutations in GATA6 have been found in neonatal diabetic patients with failed pancreatic organogenesis. To investigate the roles of GATA4 and GATA6 in mouse pancreas organogenesis, we conditionally inactivated these genes within the pancreas. Single inactivation of either gene did not have a major impact on pancreas formation, indicating functional redundancy. However, double Gata4/Gata6...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pancreas
Share to Trans-Activators
Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GATA4 Transcription Factor

Share to GATA6 Transcription Factor

Share to Homeodomain Proteins

Share to Hyperglycemia

Share to Organogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 23006330
DOI: 10.1172/JCI63240
PMCID: PMC3461915

Genes

GATA6
GATA4
PDX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GATA4 and GATA6 control mouse pancreas organogenesis.PMID 23006330Read ↗

Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis.Semantic proximity Read ↗

Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult miceSemantic proximity Read ↗

GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells.Semantic proximity Read ↗

GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.Semantic proximity Read ↗

GATA6 in pancreatic cancer initiation and progressionSemantic proximity Read ↗

GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas FormationSemantic proximity Read ↗

The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.Semantic proximity Read ↗

Cellular and molecular mechanisms coordinating pancreas developmentSemantic proximity Read ↗

GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells.Semantic proximity Read ↗

The Developmental Regulator Pax6 Is Essential for Maintenance of Islet Cell Function in the Adult Mouse PancreasSemantic proximity Read ↗

Function of GATA Factors in the Adult Mouse LiverSemantic proximity Read ↗

Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.