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Article

An investigation of mutation as a function of age in humans.

Mutation research - 1 Aug 1994

King C M, Gillespie E S, McKenna P G, Barnett Y A

Abstract excerpt

An accumulation of mutations on their own or together with other age-related changes may contribute to aging and the development of age-related pathologies. The aim of this investigation was to assess the extent of DNA mutations as a function of age in humans. The mutant frequency (MF) at the hypoxanthine-guanine phosphoribosyl-transferase (hgprt) locus was assessed in lymphocytes isolated from male volunteers in...

Topics

Adult
Aged
Aging
Cells, Cultured
Chromosome Aberrations
Confounding Factors, Epidemiologic
Humans
Hypoxanthine Phosphoribosyltransferase
Leukocyte Count
Lymphocytes
Male
Middle Aged

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Mutation

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Identifiers

PMID: 7521005
DOI: 10.1016/0921-8734(94)90010-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7521005-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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