A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study.

doi:10.1086/521151

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Article

A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study.

American journal of human genetics - 1 Oct 2007

Rutherford Sue, Cai Guowen, Lopez-Alvarenga Juan C, Kent Jack W, Voruganti V Saroja, Proffitt J Michael, Curran Joanne E, Johnson Mathew P, Dyer Thomas D, Jowett Jeremy B, Bastarrachea Raul A, Atwood Larry D, Goring Harald H H, Maccluer Jean W, Moses Eric K, Blangero John, Comuzzie Anthony G, Cole Shelley A

Abstract excerpt

Although previous genome scans have searched for quantitative-trait loci (QTLs) influencing variation in blood pressure (BP), few have investigated the rate of change in BP over time as a phenotype. Here, we compare results from genomewide scans to localize QTLs for systolic, diastolic, and mean arterial BPs (SBP, DBP, and MBP, respectively) and for rates of change in systolic, diastolic, and mean arterial BPs...

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PMID: 17846999
DOI: 10.1086/521151
PMCID: PMC2227924

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