Article
Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations.
American journal of human genetics - 3 Jul 2014
Ganesh Santhi K, Chasman Daniel I, Larson Martin G, Guo Xiuqing, Verwoert Germain, Bis Joshua C, Gu Xiangjun, Smith Albert V, Yang Min-Lee, Zhang Yan, Ehret Georg, Rose Lynda M, Hwang Shih-Jen, Papanicolau George J, Sijbrands Eric J, Rice Kenneth, Eiriksdottir Gudny, Pihur Vasyl, Ridker Paul M, Vasan Ramachandran S, Newton-Cheh Christopher, Raffel Leslie J, Amin Najaf, Rotter Jerome I, Liu Kiang, Launer Lenore J, Xu Ming, Caulfield Mark, Morrison Alanna C, Johnson Andrew D, Vaidya Dhananjay, Dehghan Abbas, Li Guo, Bouchard Claude, Harris Tamara B, Zhang He, Boerwinkle Eric, Siscovick David S, Gao Wei, Uitterlinden Andre G, Rivadeneira Fernando, Hofman Albert, Willer Cristen J, Franco Oscar H, Huo Yong, Witteman Jacqueline C M, Munroe Patricia B, Gudnason Vilmundur, Palmas Walter, van Duijn Cornelia, Fornage Myriam, Levy Daniel, Psaty Bruce M, Chakravarti Aravinda
Abstract excerpt
Blood pressure (BP) is a heritable, quantitative trait with intraindividual variability and susceptibility to measurement error. Genetic studies of BP generally use single-visit measurements and thus cannot remove variability occurring over months or years. We leveraged the idea that averaging BP...
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