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Article

Genome-wide linkage analysis of longitudinal phenotypes using sigma2A random effects (SSARs) fitted by Gibbs sampling.

BMC genetics - 31 Dec 2003

Palmer Lyle J, Scurrah Katrina J, Tobin Martin, Patel Sanjay R, Celedon Juan C, Burton Paul R, Weiss Scott T

Abstract excerpt

The study of change in intermediate phenotypes over time is important in genetics. In this paper we explore a new approach to phenotype definition in the genetic analysis of longitudinal phenotypes. We utilized data from the longitudinal Framingham Heart Study Family Cohort to investigate the familial aggregation and evidence for linkage to change in systolic blood pressure (SBP) over time. We used Gibbs sampling...

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Identifiers

PMID: 14975080
DOI: 10.1186/1471-2156-4-S1-S12
PMCID: PMC1866446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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