Article

Rapid response to the Alpha-1 Adrenergic Agent Phenylephrine in the Perioperative Period is Impacted by Genomics and Ancestry

2019-06-10

Abstract excerpt

<h4>Background</h4> The emergence of genomic data in biobanks and health systems offers new ways to derive medically important phenotypes, including acute phenotypes that occur during in-patient clinical care. We hypothesized that there is a genetic underpinning to the magnitude of the response to phenylephrine, an α1-adrenergic receptor agonist commonly used to treat hypotension during anesthesia and surgery. <h...

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Literature Corpus work: f6ab6f47-f5cb-5903-97a2-d47f7fe48cbc
DOI: 10.1101/664961

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