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Article

Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Aug 2007

Hughes Elizabeth D, Qu Yun Yan, Genik Suzanne J, Lyons Robert H, Pacheco Christopher D, Lieberman Andrew P, Samuelson Linda C, Nasonkin Igor O, Camper Sally A, Van Keuren Margaret L, Saunders Thomas L

Abstract excerpt

Genetically modified mouse strains derived from embryonic stem (ES) cells are powerful tools for gene function analysis. ES cells from the C57BL/6 mouse strain are not widely used to generate mouse models despite the advantage of a defined genetic background. We assessed genetic variation in six...

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Identifiers

PMID: 17828574
DOI: 10.1007/s00335-007-9054-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17828574-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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