Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics.

Molecular and cellular biology - 1 Jun 2003

Schwenk Frieder, Zevnik Branko, Brüning Jens, Röhl Mathias, Willuweit Antje, Rode Anja, Hennek Thomas, Kauselmann Gunther, Jaenisch Rudolf, Kühn Ralf

Abstract excerpt

ES cell-tetraploid (ES) mice are completely derived from embryonic stem cells and can be obtained at high efficiency upon injection of hybrid ES cells into tetraploid blastocysts. This method allows the immediate generation of targeted mouse mutants from genetically modified ES cell clones, in contrast to the standard protocol, which involves the production of chimeras and several breeding steps. To provide a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blastocyst
Share to Blood Chemical Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Energy Metabolism

Share to Genetic Engineering

Share to Hybrid Cells

Share to Morphogenesis

Share to Polyploidy

Source

Open in PubMed Open full text

Identifiers

PMID: 12748299
DOI: 10.1128/MCB.23.11.3982-3989.2003
PMCID: PMC155215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics.PMID 12748299Read ↗

Developmental and adult phenotyping directly from mutant embryonic stem cells.Semantic proximity Read ↗

F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses.Semantic proximity Read ↗

Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementationSemantic proximity Read ↗

Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation.Semantic proximity Read ↗

Cloned mice and embryonic stem cell establishment from adult somatic cells.Semantic proximity Read ↗

Hypomorphic mice.Semantic proximity Read ↗

WW6: an embryonic stem cell line with an inert genetic marker that can be traced in chimeras.Semantic proximity Read ↗

iPS cells produce viable mice through tetraploid complementationSemantic proximity Read ↗

Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line.Semantic proximity Read ↗

Utility of a C57BL/6 ES line versus 129 ES lines for targeted mutations in mice.Semantic proximity Read ↗

Improved generation of germline-competent embryonic stem cell lines from inbred mouse strains.Semantic proximity Read ↗

Phenotype of Cloned Mice: Development, Behavior, and PhysiologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.