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Article

Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics.

Molecular and cellular biology - 1 Jun 2003

Schwenk Frieder, Zevnik Branko, Brüning Jens, Röhl Mathias, Willuweit Antje, Rode Anja, Hennek Thomas, Kauselmann Gunther, Jaenisch Rudolf, Kühn Ralf

Abstract excerpt

ES cell-tetraploid (ES) mice are completely derived from embryonic stem cells and can be obtained at high efficiency upon injection of hybrid ES cells into tetraploid blastocysts. This method allows the immediate generation of targeted mouse mutants from genetically modified ES cell clones, in co...

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Identifiers

PMID: 12748299
DOI: 10.1128/MCB.23.11.3982-3989.2003
PMCID: PMC155215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12748299-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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