Article
Utility of C57BL/6J x 129/SvJae embryonic stem cells for generating chromosomal deletions: tolerance to gamma radiation and microsatellite polymorphism.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 1998
You Y, Bersgtram R, Klemm M, Nelson H, Jaenisch R, Schimenti J
Abstract excerpt
We have previously reported a method for making nested deletion complexes in mice by irradiation of ES cells. The key to this technology is that F1 hybrid ES cells (called v17.2) of the genotype (BALB/cTa x 129/SvJae) retain germline colonizing ability after exposure to levels of ionizing radiation that induce chromosomal deletions. In an effort to identify other genotypes of ES cells that are suitable for this...
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