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Article

CpG/CpNpG motifs in the coding region are preferred sites for mutagenesis in the breast cancer susceptibility genes.

FEBS letters - 2 Oct 2007

Cheung Lydia W T, Lee Yiu Fai, Ng Tuen Wai, Ching Wai Ki, Khoo Ui Soon, Ng Michael K P, Wong Alice S T

Abstract excerpt

The range of BRCA1/BRCA2 gene mutations is diverse and the mechanism accounting for this heterogeneity is obscure. To gain insight into the endogenous mutational mechanisms involved, we evaluated the association of specific sequences (i.e. CpG/CpNpG motifs, homonucleotides, short repeats) and mut...

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Source

Identifiers

PMID: 17826769
DOI: 10.1016/j.febslet.2007.08.061

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17826769-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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