Article
In silico discrimination of single nucleotide polymorphisms and pathological mutations in human gene promoter regions by means of local DNA sequence context and regularity.
In silico biology - 1 Jan 2006
Khan Imtiaz A, Mort Matthew, Buckland Paul R, O'Donovan Michael C, Cooper David N, Chuzhanova Nadia A
Abstract excerpt
DNA sequence features were sought that could be used for the in silico ascertainment of the likely functional consequences of single nucleotide changes in human gene promoter regions. To identify relevant features of the local DNA sequence context, we transformed into consensus tables the nucleot...
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