Article
Chromosome morphogenesis: condensin-dependent cohesin removal during meiosis.
Cell - 4 Nov 2005
Yu Hong-Guo, Koshland Douglas
Abstract excerpt
During meiosis, segregation of homologous chromosomes necessitates the coordination of sister chromatid cohesion, chromosome condensation, and recombination. Cohesion and condensation require the SMC complexes, cohesin and condensin, respectively. Here we use budding yeast Saccharomyces cerevisiae to show that condensin and Cdc5, a Polo-like kinase, facilitate the removal of cohesin from chromosomes prior to the...
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