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<i>Runx1</i>Protects Hematopoietic Stem/Progenitor Cells from Oncogenic Insult

6 Sept 2007

Abstract excerpt

The RUNX1/AML1 gene encodes a transcription factor essential for the generation of hematopoietic stem cells and is frequently targeted in human leukemia. In human RUNX1-related leukemias, the RAS pathway is often concurrently mutated, but the mechanism of the synergism remains elusive. Here, we found that inactivation of Runx1 in mouse bone marrow cells results in an increase in the stem/progenitor cell fraction...

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Identifiers

PMID: 17823240
DOI: 10.1634/stemcells.2007-0061

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