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Hypoxia‐inducible factor‐1 and oncogenic signalling

21 Feb 2004

Abstract excerpt

An understanding of underlying mechanisms involved in the activation of HIF-1 in response to both hypoxic stress and oncogenic signals has important implications for how these processes may become deregulated in human cancer. Changes in microenvironmental stimuli such as hypoxia and growth factors in combination with genetic lesions, such as loss or inactivation of p53, PTEN or pVHL or oncogenic activation, can...

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PMID: 14988927
DOI: 10.1002/bies.20002

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