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Article

The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells

1 Apr 1992

Abstract excerpt

Previous studies have shown that the E7 gene of human papillomavirus (HPV) type 16 or 18 alone was sufficient for immortalization of human foreskin epithelial cells (HFE) and that the efficiency was increased in cooperation with the respective E6 gene, whereas the HPV6 E6 or E7 gene was not active in HFE. To detect weak immortalizing activities of the HPV6 genes, cells were infected with recombinant retroviruses...

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PMID: 1312623
DOI: 10.1128/jvi.66.4.2125-2134.1992

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The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cellsPMID 1312623Read ↗

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Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.Semantic proximity Read ↗

Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18Semantic proximity Read ↗

The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in cultureSemantic proximity Read ↗

Myc and Human Papillomavirus Type 16 E7 Genes Cooperate To Immortalize Human KeratinocytesSemantic proximity Read ↗

The Asian-American E6 variant protein of human papillomavirus 16 alone is sufficient to promote immortalization, transformation, and migration of primary human foreskin keratinocytes.Semantic proximity Read ↗

Roles of the E6 and E7 proteins in the life cycle of low-risk human papillomavirus type 11.Semantic proximity Read ↗

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