Article
Common variation in the platelet receptor P2RY12 gene is associated with residual on-clopidogrel platelet reactivity in patients undergoing elective percutaneous coronary interventions.
Circulation. Cardiovascular genetics - 1 Oct 2009
Rudez Goran, Bouman Heleen J, van Werkum Jochem W, Leebeek Frank W G, Kruit Adrian, Ruven Hendrik J T, ten Berg Jurriën M, de Maat Moniek P M, Hackeng Christian M
Abstract excerpt
BACKGROUND: The clinical efficacy of clopidogrel is hampered by a large interindividual variability in platelet inhibition. Polymorphisms in the P2RY12 receptor gene have been suggested to contribute to this variability, but previous studies included a relatively small number of patients and incompletely covered the common variation in the P2RY12 gene. The aim of this study was to comprehensively investigate the...
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