Article
Effects of serum TSH and FT4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam Study.
Clinical endocrinology - 1 Feb 2008
van der Deure Wendy M, Uitterlinden André G, Hofman Albert, Rivadeneira Fernando, Pols Huibert A P, Peeters Robin P, Visser Theo J
Abstract excerpt
BACKGROUND: TSH and thyroid hormone may have independent effects on bone. In this study we investigated the association of TSH and free T4 (FT4) with different bone parameters in human subjects. TSH and FT4 are known to be associated with body mass index (BMI) and a higher BMI gives a higher bone mineral density (BMD). Thus, we aimed to determine whether the effects of TSH and FT4 on bone are mediated by BMI. As...
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