Article
Identification and consequences of polymorphisms in the thyroid hormone receptor alpha and beta genes.
Thyroid : official journal of the American Thyroid Association - 1 Oct 2008
Sørensen Helena Gásdal, van der Deure Wendy M, Hansen Pia Skov, Peeters Robin P, Breteler Monique M B, Kyvik Kirsten Ohm, Sørensen Thorkild I A, Hegedüs Laszlo, Visser Theo J
Abstract excerpt
OBJECTIVE: Genetic factors exert considerable influence on thyroid function variables. Single nucleotide polymorphisms (SNPs) in thyroid hormone pathway genes have been associated with serum thyroid parameters implying small alterations in the hypothalamus-pituitary-thyroid axis. However, little is known about SNPs in the THRA (17q11.2) and THRB (3p24.2) genes. The aim of this study was to map THRA and THRB for...
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