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Article

Thyroid Stimulating Hormone and Bone Mineral Density: Evidence From a Two-Sample Mendelian Randomization Study and a Candidate Gene Association Study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2018

van Vliet Nicolien A, Noordam Raymond, van Klinken Jan B, Westendorp Rudi Gj, Bassett Jh Duncan, Williams Graham R, van Heemst Diana

Abstract excerpt

With population aging, prevalence of low bone mineral density (BMD) and associated fracture risk are increased. To determine whether low circulating thyroid stimulating hormone (TSH) levels within the normal range are causally related to BMD, we conducted a two-sample Mendelian randomization (MR) study. Furthermore, we tested whether common genetic variants in the TSH receptor (TSHR) gene and genetic variants...

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Identifiers

PMID: 29544020
DOI: 10.1002/jbmr.3426

Genes

TSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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