Article
LRRK2 is not a significant cause of Parkinson's disease in French-Canadians.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques - 1 Aug 2007
Dupré Nicolas, Rivière Jean-Baptiste, Myers Richard H, Provencher Pierre, Pourcher Emmanuelle, Emond François, Rouleau Guy A
Abstract excerpt
BACKGROUND: An old founder mutation (G2019S) was found with high frequency in the North African Arabs (30%) and Ashkenazi Jews (18% ). OBJECTIVE: Demonstrate if mutations in the LRRK2 gene are a significant cause of Parkinson's disease (PD) in the French-Canadian founder population. METHODS: Cases were recruited through a designated movement disorder clinic in Quebec City. Every index case had to meet the Ward...
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