Article
Flow cytometric measurements of somatic cell mutations in Thorotrast patients.
Japanese journal of cancer research : Gann - 1 Dec 1991
Umeki S, Kyoizumi S, Kusunoki Y, Nakamura N, Sasaki M, Mori T, Ishikawa Y, Cologne J B, Akiyama M
Abstract excerpt
Exposure to ionizing radiation has long been well-recognized as a risk factor for cancer development. Since ionizing radiation can induce mutations, an accurate way of measuring somatic mutation frequencies could be a useful tool for evaluating cancer risks. In the present study, we have examined in vivo somatic mutation frequencies at the erythrocyte glycophorin A (GPA) and T-cell receptor (TCR) loci in 18...
Topics
- Aged
- Aged, 80 and over
- Antibodies, Monoclonal
- Erythrocytes
- Flow Cytometry
- Glycophorins
- Heterozygote
- Humans
- Lymphocytes
- Male
- Mutation
- Neoplasms, Radiation-Induced