Article
HIF-dependent antitumorigenic effect of antioxidants in vivo.
Cancer cell - 1 Sept 2007
Gao Ping, Zhang Huafeng, Dinavahi Ramani, Li Feng, Xiang Yan, Raman Venu, Bhujwalla Zaver M, Felsher Dean W, Cheng Linzhao, Pevsner Jonathan, Lee Linda A, Semenza Gregg L, Dang Chi V
Abstract excerpt
The antitumorigenic activity of antioxidants has been presumed to arise from their ability to squelch DNA damage and genomic instability mediated by reactive oxygen species (ROS). Here, we report that antioxidants inhibited three tumorigenic models in vivo. Inhibition of a MYC-dependent human B lymphoma model was unassociated with genomic instability but was linked to diminished hypoxia-inducible factor (HIF)-1...
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