Article
Amphetamine-induced behavioral phenotype in a hypoxanthine-guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome.
Behavioral neuroscience - 1 Dec 1991
Jinnah H A, Gage F H, Friedmann T
Abstract excerpt
In humans, congenital deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) results in a disorder known as the Lesch-Nyhan syndrome. Patients with this disorder exhibit a prominent neurobehavioral phenotype that results in part from dysfunction of catecholaminergic systems in the striatum. HPRT-deficient mice produced as animal models for this syndrome curiously exhibit no spontaneous...
Topics
- Animals
- Brain
- Catecholamines
- Chromosome Deletion
- Dextroamphetamine
- Hypoxanthine Phosphoribosyltransferase
- Lesch-Nyhan Syndrome
- Mice
- Mice, Neurologic Mutants
- Motor Activity
- Phenotype