Absence of the HLA-G*0105N allele in Amerindian populations from the Brazilian Amazon Region: a possible role of natural selection.

doi:10.1111/j.1399-0039.2007.00910.x

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Article

Absence of the HLA-G*0105N allele in Amerindian populations from the Brazilian Amazon Region: a possible role of natural selection.

Tissue antigens - 1 Oct 2007

Mendes-Junior C T, Castelli E C, Simões A L, Donadi E A

Abstract excerpt

The human leukocyte antigen G (HLA-G) null allele (G*0105N) is defined by a DeltaC deletion at exon 3. Its high frequency in populations from areas with high pathogen loads and the putative role of HLA-G in placental development suggest that the reduced G1 expression in G*0105N heterozygous placentas may improve the intrauterine defense against infections. The G*0105N allele frequencies were evaluated in 143...

Topics

Alleles
Brazil
Female
Gene Frequency
Genetics, Population
Genotype
HLA Antigens
HLA-G Antigens
Humans
Indians, South American
Male
Polymorphism, Genetic
Selection, Genetic

Source

Open in PubMed

Identifiers

PMID: 17767556
DOI: 10.1111/j.1399-0039.2007.00910.x

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