Article
Absence of the HLA-G*0113N allele in Amerindian populations from the Brazilian Amazon region.
Human immunology - 1 Apr 2010
Mendes-Junior Celso T, Castelli Erick C, Moreau Philippe, Simões Aguinaldo L, Donadi Eduardo A
Abstract excerpt
The HLA-G gene is predominantly expressed at the maternal-fetal interface and has been associated with maternal-fetal tolerance. The HLA-G*0113N is a null allele defined by the insertion of a premature stop codon at exon 2, observed in a single Ghanaian individual. Likewise the G*0105N allele, the occurrence of the HLA-G*0113N in a population from an area with high pathogen load suggests that the reduced HLA-G...
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