Article
Insights on the HLA-G evolutionary history provided by a nearby Alu insertion.
Molecular biology and evolution - 1 Nov 2013
Santos Kaisson E, Lima Thálitta H A, Felício Leandro P, Massaro Juliana D, Palomino Gustavo M, Silva Ana Carolina A, Oliveira Silviene F, Sabbagh Audrey, Garcia Andre, Moreau Philippe, Donadi Eduardo A, Mendes-Junior Celso T, Castelli Erick C
Abstract excerpt
The AluyHG element belongs to the AluYb8 subfamily. It is a polymorphic insertion, located approximately 20 kb from the HLA-G 3'-untranslated region (3'-UTR), which has been used for evolution studies because it exhibits identity for descendants and it is still polymorphic in the human genome. To understand the evolutionary mechanisms acting on HLA-G, we evaluated the presence or absence of the AluyHG element,...
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