Article
HLA-G alleles and their impacts on placental HSV-1 infection in women from southern Brazil.
Journal of reproductive immunology - 1 Sept 2023
Tornatore Michele, Amaral Suélen Cavalheiro, Alves Brunna M, de Oliveira Gisele Rodrigues, Finger-Jardim Fabiana, Avila Emiliana Claro, Pivato Andressa Fernandes, Lobato Rubens Caurio, Chies José Artur Bogo, Ellwanger Joel Henrique, Soares Esmeralda A, Sánchez-Luquez Karen, Gonçalves Carla Vitola, Martínez Ana Maria Barral de, Soares Marcelo A, da Hora Vanusa Pousada
Abstract excerpt
The Human Leukocyte Antigen G (HLA-G) is an immunoregulatory molecule with a critical role in pregnancy success. HLA-G alleles are associated with differential susceptibility to multiple conditions, including gestational problems, infectious diseases, and viral persistence. Of note, both herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) can impair HLA-G expression, interfering with HLA-G-associated...
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