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A genetic approach to stratification of risk for age-related macular degeneration.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie - 1 Feb 2010

Zanke Brent, Hawken Steven, Carter Ronald, Chow David

Abstract excerpt

The genetic determinants of age-related macular degeneration (AMD) are reviewed and a novel approach to risk determination based upon inherited genetic polymorphisms and smoking history is presented. Although AMD was long thought to have primarily an environmental etiology, genetic variation is now known to account for the majority of the disease risk, with variations in the genes of the complement pathways...

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Algorithms
Complement System Proteins
Environment
Macular Degeneration
Oxidative Phosphorylation

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PMID: 20130705
DOI: 10.3129/i09-209

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