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Article

Menin-mediated Caspase 8 Expression in Suppressing Multiple Endocrine Neoplasia Type 1

31 Aug 2007

Abstract excerpt

Multiple endocrine neoplasia type 1 (MEN1) is a familial tumor syndrome linked to mutation of the MEN1 gene, which encodes a tumor suppressor, menin. We previously reported that menin up-regulates the caspase 8 expression and promotes TNF-alpha-induced apoptosis. However, it remains unclear how menin up-regulates caspase 8 expression and whether menin-mediated caspase 8 expression plays a role in repressing MEN1...

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PMID: 17766243
DOI: 10.1074/jbc.m609555200

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