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Tumor Suppressor Menin Regulates Expression of Insulin-Like Growth Factor Binding Protein 2

30 Mar 2004

Abstract excerpt

Multiple endocrine neoplasia type I (MEN1) is an inherited tumor syndrome characterized by development of tumors in multiple endocrine organs. The gene mutated in MEN1 patients, Men1, encodes a nuclear protein, menin. Menin interacts with several transcription factors and inhibits their activities. However, it is unclear whether menin is essential for the repression of the expression of endogenous genes. Here,...

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PMID: 15044367
DOI: 10.1210/en.2004-0124

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