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Article

Inducing rigid local structure around the zinc-binding region by hydrophobic interactions enhances the homotrimerization and apoptotic activity of zinc-free TRAIL.

Biochemical and biophysical research communications - 26 Oct 2007

Lee Hyun-Wook, Kim Tae-In, Chan Khon Huynh, Kwon Myung-Hee, Kim Jeong-Sun, Jin Moonsoo, Kim Yong-Sung

Abstract excerpt

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), existing as homotrimer in solution, contains a unique zinc-binding site coordinated by three Cys230 residues at the tip of trimeric interface. TRAIL mutant with replacements of Cys230 with Ala (TRAIL(C230A)) negligibly formed trimeric structure and showed no apoptotic activity. Here, to elucidate the relationship between the trimeric stability and...

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Identifiers

PMID: 17765202
DOI: 10.1016/j.bbrc.2007.08.075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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